Lithium Treatment and Thyroid Disorders
نویسندگان
چکیده
Lithium was first discovered as a chemical element in 1817. By the mid-1800s, there was great interest in “urate imbalances”, which were thought to explain a variety of diseases, including mania and depression. Around this time, it was discovered that a solution of lithium carbonate could dissolve stones made of urate. The first recorded use of lithium for the treatment of mania, based in part on the urate/lithium connection, was 1871. Use of lithium carbonate which is the current pill form of lithium to prevent depression came in 1886 [1].
منابع مشابه
Effects of Long-term Lithium Carbonate Treatment on Thyroid Function in Psychiatric Patients
The effect of long-term lithium carbonate treatment on thyroid function was investigated in 40 clinically euthyroid patients with Manic Depressive Psychosis. Before lithium treatment, all patients showed normal levels (T(4)) of serum total thyroxine, free thyroxine index and thyrotropin (TSH). After lithium carbonate treatment for a mean period of 24 months, these patients did not show any sign...
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OBJECTIVE Because the role of thyroid autoimmunity in the development of lithium-induced thyroid dysfunction remains controversial, we compared the prevalence of thyroid autoantibodies in patients with affective disorders receiving long-term lithium maintenance therapy with that of age- and sex-matched controls. METHODS We conducted a cross-sectional study with 100 adult patients with major a...
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The relationship between mood disorders and abnormalities of the endocrine and immune systems have been described (Horning et al. 1998, Kanba et al. 1998). Thyroid abnormalities associated with lithium treatment have been widely reported, including goiter, hypothyroidism, hyperthyroidism, and autoimmune thyroiditis (Kibirige et al. 2013). The presence of antithyroid antibody titers in bipolar p...
متن کاملLithium Therapy and Thyroid Disorders
Lithium carbonate is used as a first-line treatment for bipolar disorder and is given to approximately 1 in every 200 patients with this psychiatric disease. Lithium, an element in the alkali metal group, has a variety of anti-thyroid effects, primarily goiter formation and hypothyroidism. Rarely, lithium may cause hyperthyroidism secondary to thyroiditis or through possible autoimmune actions....
متن کاملLithium treatment and thyroid abnormalities
BACKGROUND Although the interactions between lithium treatment and thyroid function have long been recognised, their clinical relevance is still controversial. This paper sets out a review of the literature to date, considering that lithium still represents the gold standard among prophylactic treatments of manic-depression several decades after its introduction. METHOD PubMed database was us...
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